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Dutasteride Dutasteride, like finasteride, inhibits the action of the enzyme 5 alpha-reductase and hence blocks the production of DHT. However, there are in fact two forms of 5-alpha reductase and whereas finasteride only inhibits one type, dutasteride inhibits both types. At the time of writing Dutasteride is to be used for the treatment of Benign Prostatic Hyperplasia (BPH). However, there is much speculation that this substance would be a very effective treatment for hair loss and it is hoped by many that clinical trials specifically related to hair loss will be concluded. Like finasteride, it would be a male only treatment and, because of the nature of its action, could give rise to side effects such as loss of sexual appetite in certain individuals.

Female Hair Loss Perhaps surprisingly there is a strong connection between male pattern baldness (MPB) and the typical hair loss patterns seen in females. As well as having the necessary enzyme (5-alpha reductase) capable of forming DHT from the male hormone testosterone (everyone has both male and female hormones) a woman also has an enzyme called aromatise which converts some male hormone into a female type. This has the effect that much of the hair loss which would have occurred is reversed or prevented by the counterbalancing effect of this ‘extra’ female type hormone in the area of the hair roots. As a result it would be extremely unusual for a female to lose as much hair as, say, her brother, even though she may have inherited similar genetic information. 

Stopping thinning hair and hair loss has always been a problem, but thanks to two medical hair loss treatments, namely Minoxidil and Finasteride, baldness may be delayed. Generic Minoxidil may have enhancers added, such as progesterone, nicotinate, tretinoin, Finasteride and azelaic acid. Hair loss especially when severe, affects the lives of those afflicted. This evokes loss of self-esteem, alterations in self image and loss of self-identity. Hairloss treatments may provide a sense of well being to those who are suffering from hairloss.

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