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Male pattern baldness (MPB) is principally caused by two main factors - possibly assisted by some other more minor ones. The two factors are: Presence of a substance called Dihydrotestosterone (DHT) in the vicinity of the hair roots. This substance is produced from the male hormone testosterone by the action of a particular enzyme called 5-alpha reductase. Inherited genetic information. When a man inherits the necessary gene for some of his hair roots to become susceptible to attack by DHT he will lose hair. MPB therefore has nothing to do with the amount of male hormone a man has - merely the fact that he has any at all is enough to cause the hair loss provided he has also inherited the necessary genetic detail. Only those hair roots which have been programmed will be attacked by DHT. Normally these will be somewhere through the top region of the scalp with at least those hair roots around the sides and back of the scalp not being susceptible to attack by DHT. Hence, many men are left with a ‘monks fringe’ of hair at the sides and back. The chart below outlines the normal progression of male pattern baldness:Azelaic Acid Whilst minoxidil promotes hair growth, Azelaic Acid reduces hair loss. A very weak acid, (much weaker than vinegar for example), that is found in some whole grains. Recent studies have shown it to be a very potent inhibitor of the enzyme 5- alpha reductase which is responsible for the formation of DHT - the primary substance responsible for hair loss. Many experts believe that azelaic acid will therefore work synergistically with minoxidil - the azelaic acid reducing hair loss whilst the minoxidil promotes hair growth. Note that exposure to direct sunlight needs to be avoided if using this item as it may cause irritation. Some people therefore apply at night and then apply a minoxidil only item during the day. Progesterone A female hormone added in very small quantities. Its effect is to neutralise the local action of the male hormone derivative DHT which is responsible for hair loss.
Stopping thinning hair and hair loss has always been a problem, but thanks to two medical hair loss treatments, namely Minoxidil and Finasteride, baldness may be delayed. Generic Minoxidil may have enhancers added, such as progesterone, nicotinate, tretinoin, Finasteride and azelaic acid. Hair loss especially when severe, affects the lives of those afflicted. This evokes loss of self-esteem, alterations in self image and loss of self-identity. Hairloss treatments may provide a sense of well being to those who are suffering from hairloss.